Transmission Through Sexual Acts

There are many sexual acts during which HIV can be transmitted and just as many myths surrounding who can and who can't get Aids

Transmission Through Sexual Acts - There are many sexual acts during which HIV can be transmitted and just as many myths surrounding who can and who can't get Aids. Misconceptions also abound as to how the virus can and can't be transmitted during sex.

Transmission Through Sexual Acts

Sexual intercourse with an HIV-infected person

HIV infection is sexually transmitted primarily through unprotected vaginal or anal intercourse (i.e. sexual intercourse without a condom), as well as through oral sex under certain conditions.


How does HIV get into the body during sexual contact? 

To gain entry into the body of an uninfected person, the HI virus needs to bind or “latch onto” target cells with specific receptors (namely CD4 receptors) on its surface. Cells with these special receptors are plentiful in the lining of the genital track and that of the anus.

During unprotected sex with an HIV+ person, the virus (in the sexual fluids of the infected person) binds with the CD4 receptors in the lining of the genital tracks (e.g. vagina) or anal track of the uninfected partner.

Tears (often microscopically small) in the membrane linings of the genital tracks - especially in the anal-rectal area - also make it easy for the virus to enter the sex partner’s bloodstream. Because the membrane linings of body cavities - especially in the anal-rectal area, and, to a lesser extent, in the vagina - are very delicate, they can be torn as a result of friction generated during sexual intercourse. (Rough sex, dry sex and forced sex or rape often lead to friction, tears and bleeding.)

Sexually transmitted infections (STIs), such as syphilis, gonorrhoea or herpes, make it very easy for HIV to get into the body. An untreated STI in either partner increases the risk of HIV transmission during unprotected intercourse ten-fold.

People with genital herpes or genital ulcers or sores are especially susceptible to HIV infection because these conditions create openings in the linings of the genital tracks through which HIV can move. The discharges produced by many STIs contain a very high concentration of HIV if that person is also HIV positive.

Why are women more easily infected by HIV than men?

Women are two to four times more likely to get infected with HIV through unprotected vaginal sex than men, due to the following reasons:

Women, as the recipients of semen, are exposed to semen for a longer time (while semen remains in the body of a woman for a few hours, a man is exposed to the body fluids of a woman for only a short time);
The concentration of HIV in semen is much higher than the concentration of HIV in vaginal fluids;
Women possess a larger surface area of mucosa (the thin lining of the vagina and cervix) which is exposed to their partner’s secretions during sexual intercourse;
Many women have cervical or vaginal conditions, such as STIs, erosions, open sores and infections, that facilitate the transmission of HIV;
Many women practise “dry” sex and they cause damage or infection to the vaginal walls (“dry” sex is a cultural practice where women use herbs or other substances - such as Jik or washing powder - to dry out their vaginas for the benefit of some men who believe that a dry vagina is a sign of faithfulness, or to heighten their sexual pleasure.) This practice is painful and extremely dangerous because it increases the risk of HIV infection;
Transmission of HIV is more likely to occur just before, during or immediately after menstruation because of the large, raw area of the inner uterine lining that is exposed;
Younger women are especially vulnerable to HIV infection because their genital tracts are not yet fully mature, their vaginal secretions are not so copious, and because they are more prone to lacerations or tears of the vaginal lining. (There is also evidence to suggest that women once again become more vulnerable to HIV infection after menopause).
Women often practice anal sex to avoid pregnancy, to maintain “virginity”, or because their male partners prefer anal sex for reasons similar to the reasons why they prefer “dry sex”. Research has shown that the chances to become infected with HIV after one act of unprotected receptive anal sex is approximately 20 times greater than after one act of unprotected vaginal sex.
Social inequalities often make women more vulnerable to HIV infection especially in societies which accord women a lower status than men. Women in such situations have little or no control over their sex lives, and they are not in a position to negotiate safer sex practices because they fear violence and abandonment should they try to do so. Women from low socio-economic environments are often driven to prostitution, and they are particularly vulnerable to rape.

Can lesbians get Aids?

Yes, lesbian women can also get Aids.

Lesbians who have sex with women as well as men, can contract HIV infection if they have sex with infected men.

Although the risk of HIV-infection is small for women who have sex exclusively with other women, lesbian women can contract HIV infection by sharing contaminated sex toys (e.g. vibrators or dildo’s) for vaginal or anal penetration. Because sex toys can cause bleeding or irritation of the vaginal or anal lining, it is easier for the HI virus to enter the body if people use them or share them. When sex toys are used, they should be thoroughly cleaned and preferably not shared, but if they are shared, the sex toy should be covered with a condom (a new condom for each partner!).

It should also be kept in mind that menstruation blood of an HIV+ woman is contagious. A plastic/latex cover such as “glad wrap”, a dental dam, or a condom that is cut open, should be placed over the vagina for oral sex (also for heterosexual oral sex with a woman).


Can one be infected with HIV through having oral sex?

Oral sex (stimulation of the penis with the mouth, or stimulation of female genitals with the lips and tongue) may cause a person to become infected with HIV if the lining of the partner’s mouth is exposed to infected seminal fluid or vaginal and rectal mucus - especially if the person providing the oral stimulation has sores, bleeding gums or inflammation in his or her mouth. Keep in mind that the virus occurs in high concentrations in semen and in menstrual blood.

A condom should always be used for oral sex on a man (also called fellatio), and a plastic/latex cover such as “glad wrap”, a dental dam, or a condom that is cut open, for oral sex on a women (also called cunnilingus).

How many sexual contacts with an HIV-positive person are necessary before one becomes infected oneself?

It is impossible to say how many sexual contacts with an infected partner/s are necessary before an HIV-negative person becomes HIV-positive.

HIV transmission from one person to another through sexual contact can depend on any of the following factors:

Unprotected (without a condom) sex with multiple sex partners.
The presence of other STIs (sexually transmitted infections), especially in the case of genital ulcers and inflammatory STIs.
Trauma (or bleeding) during sex, as well as menstruation.
The viral concentration (or level of viral “load”) in the blood of the infected partner.
The level of viral load in the semen or vaginal fluids of the infected partner (Viral load in semen peaks three weeks after infection. HIV is 20 times more transmissible per sex act, at this stage.)
The phase of infection. HIV is much more contagious in the acute infection phase (first eight to 12 weeks after infection) as well as in the final phases when advanced disease (or Aids) has set in. The reason why HIV is easier transmitted during these phases, is because the viral load is especially high in the acute infection phase, and again in the final phase of Aids.
When the immune system is suppressed (this is also then an indication of a high viral load and a low CD4 count.
Other diseases such as malaria. The HIV viral load is very high in people who also have malaria.
HIV-1 subtype C is more infectious than other subtypes, and subtype C is unfortunately the viral subtype that occurs in South Africa.

Is it true that circumcision can protect males against HIV infection?

Several studies reported at the Aids conference in Barcelona (2002) indicated that circumcision can indeed reduce the risk of HIV infection for the circumcised male, but:

It seems that circumcision only provides a measure of protection if the circumcision was done before the boy reached puberty (cancel those appointments men!)
The direction of effectivity is not clear yet (in other words, will male circumcision also lower the risk of male to female transmission - and protect the sex partner?)
If the circumcision procedure is done with unsterilised, dirty blades (or other instruments) - as often happens in Africa - HIV-infected blood could pass from one boy (or male) to another.
Although circumcision may lower the risk of HIV infection in circumcised men, circumcision should definitely not be promoted as the only way of preventing HIV infection! Safer sex practices such as the use of condoms should always be practised, disregarding circumcision or not!
Read: How circumcision reduces HIV risk

If I am HIV+, why should I still use a condom to protect myself?

HIV+ individuals still need to protect themselves against re-infections with HIV, for the following reasons:

Each new infection can cause an increase in the viral load in the blood and
The person can become infected with a new strain of the virus. It is therefore important for HIV+ people to protect themselves from re-infection by always using condoms.

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The Most Common Male Cancers

Detecting cancer early can save your life. Know the facts about each of the most common male cancers

The Most Common Male Cancers - Cancer has a number of platforms to drive awareness these days.

Many organisations, worldwide, have made it their business to educate the public, while entire months have been dedicated to highlighting information about the various types of cancer.
The Most Common Male Cancers

These are some of the most common types of male cancers.

Testicular cancer
If the cancer starts in the testicles, it would be called testicular cancer. As for how it develops, it would be useful to begin by talking about what testicles do. That is, they make male hormones such as testosterone. They also make sperm. 

Upwards of 90% of testicular cancers grow in special cells called germ cells. They’re the cells that produce sperm. There are two main types of germ cell tumours in men.

The first type, called seminomas, can take two forms. More than 95% of them are called classical seminomas, and they tend to occur in men between the ages of 25 and 45. Spermatocylic seminomas are rarer, develop more slowly, and tend to occur in men who are around 65.

Seminomas usually develop and spread less quickly than non-seminomas. The latter type of germ cell tumours ordinarily occur in men who are between their late teens and early 30s.

Prostate cancer
The prostate is found below the urinary bladder and in front of the rectum. Although there are many types of cells in the prostate, just about all prostate cancers grow from gland cells. These are the cells that produce prostate fluid – which is added to semen.

In the UK, prostate cancer tends to affect men over the age of 50, with the average age of diagnosis being between 70 and 74.

Bladder cancer
The bladder is a hollow organ in the pelvis, and its main purpose is to store urine prior to it leaving the body. It has flexible, muscular walls that have four primary layers: the urothelium, thelamina propia, the muscularis propia and, finally, a layer of fatty connective tissue to keep the bladder separate from nearby organs.

It’s important to be familiar with these layers when considering how bladder cancers develop. Most of them start in the urothelium[13]. Bladder cancers become more difficult to treat as they grow into or throughout the other layers.

Given that it ordinarily takes a long time to grow, bladder cancer usually occurs in people over 60.

Early treatment
As with many other types of cancer, the basic rule is that early detection can save lives.  That’s because it’s easier to treat if you diagnose it before it’s got too big or spread.
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Ankle Injuries Could Have Long-Term Effects

A recent study found that people with injured ankles tend to have higher rates of disability and arthritis, heart or respiratory issues going forward

Ankle Injuries Could Have Long-Term Effects - Many Americans have suffered through an ankle break or sprain, but new research suggests these injuries might have a larger effect on health.
Ankle Injuries Could Have Long-Term Effects

Proper rehabilitation
The study, based on a survey of thousands of adults, found that people with injured ankles tend to have higher rates of disability and arthritis, heart or respiratory issues going forward.

The study can't prove cause-and-effect, but it points to the importance of proper rehabilitation after ankle injuries, the researchers said.

"What is concerning is these differences are presenting across the life span – especially during the critical middle age years when our risk for these diseases begins to increase," said study author Phillip Gribble.

He's an associate professor in the department of rehabilitation sciences at the University of Kentucky, in Lexington.

In the study, Gribble's team conducted an online survey of over 3,500 adults. More than 1,800 of them said they had sustained some kind of ankle injury at some point in their lives.


Relatively benign injuries

Those who'd had such injuries were more likely to say they were "somewhat" to "completely" limited in their daily activities compared to people without such histories, at 46 percent vs. 36 percent, respectively. Rates of moderate to severe body pain were also higher (38 percent vs. about 27 percent).

The study also found higher rates of heart or respiratory ailments in people who'd injured their ankle versus those who hadn't (about 31 percent vs. 24.5 percent, respectively).

Not surprisingly, arthritis of the ankle was also much more likely among those who previously injured the joint (9.4 percent) compared to those who hadn't (1.8 percent), Gribble's team found.

Overall, the findings suggest that ankle breaks and strains should be taken more seriously, the researchers said.

"In isolation, ankle injuries are seen as relatively benign and inconsequential injuries," noted Gribble, who is also co-director of the International Ankle Consortium, a specialist research group.

"This is not just a problem for athletes, as a large percentage of the population reports chronic ankle issues," he noted. "Better efforts are needed to prevent the initial injuries, and also to introduce improved interventions post-injury, to reduce the high rate of chronicity we see in ankle injury patients."

Another expert in athletic injury agreed

The study "supports other research reporting the negative long-term effects of an ankle sprain," said Tricia Hubbard-Turner, an associate professor at the Centre for Biomedical Engineering Systems at the University of North Carolina at Charlotte.

Enabling healing and rehabilitation

"The take-home message should be there is no such thing as 'just an ankle sprain'," she said.

Hubbard-Turner offered advice on proper recovery from an ankle injury:

- Give the ankle adequate time to rest and heal.

- Use crutches if possible during the healing process, and begin a rehab exercise regimen once healing occurs.

- Exercise could include: "motion exercises [pointing toes up and down, writing the alphabet with your feet], strengthening [tubing exercises, cuff weight around the foot], balance exercises [standing on one leg] and more functional activities [light jogging, zigzags, figure eights] before returning to activity," she said.

"Enabling healing and rehabilitation is key to preventing the negative consequences reported in the Gribble study," Hubbard-Turner said.

"This may mean missing sports activity or modifying exercise [for example, trying non-weight bearing exercise] for a few weeks, depending on the severity of injury," she acknowledged. "But those few weeks are well worth it based on the long-term problems people are developing."

The study was to be presented at the annual meeting of the National Athletic Trainers' Association in Baltimore. Experts note that research presented at medical meetings is typically considered preliminary until published in a peer-reviewed journal.
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Circumcision On The Rise At Africa’s Only Specialised Urology Hospital

Medical circumcisions are on the rise at Africa's only specialised urology hospital as more men hope to reduce their risk of HIV and other sexually transmitted infections


Circumcision on the rise at Africa’s only specialised urology hospital - Medical circumcision is on the rise at The Urology Hospital in SA as more males seek to minimise the risk of contracting HIV, STIs and other urinary infections.

The World Health Organisation (WHO) says there is compelling evidence that male circumcision reduces the risk of heterosexually-acquired HIV infection by about 60% and recommends this procedure for HIV prevention.
Circumcision On The Rise At Africa’s Only Specialised Urology Hospital
The WHO says 10-million men sought voluntary medical circumcision in sub-Saharan Africa over the last five years.

The Urology Hospital in Pretoria, Africa’s only specialist urology institution, notes that the number of circumcisions there have increased by 42% since 2012.

“This is largely due to the fact that more people are becoming aware of the health advantages of circumcision, notably in HIV prevention,” said the hospital’s Dr Odion Aire.

In some African communities, circumcision at initiation schools is a rite of passage to manhood and is sometimes characterised by medical complications. In the Eastern Cape, for example, an average of 50 deaths were reported a year since 2012 due to botched circumcisions.

In SA where almost 18% of the population is living with HIV, the government’s National Strategic Plan on HIV, STI’s and TB includes promoting male circumcision to decrease HIV infections.

Advantages of circumcision:

- Reduces the spread of viral STDs, HIV, herpes, Human Papillomavirus (HPV) and cervical cancer

- Lowers the risk of developing penile cancer

- Reduces the risk of passing the virus that causes cervical cancer to female partners

Perceived disadvantages:

- Decrease of sexual stimulus
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Type 2 Diabetes And Heart Disease a Dangerous Combination

The reason heart disease and type 2 diabetes are linked is partly because obesity and problems such as high blood pressure and high cholesterol levels

Type 2 Diabetes And Heart Disease a Dangerous CombinationProspects for people with type 2 diabetes and heart disease may be grimmer than previously believed, researchers report.

"Type 2 diabetes accompanied by an acute coronary syndrome needs much more attention, especially in order to prevent yet another major cardiac event," said study leader Dr William White. He is a professor with the University of Connecticut Health Centre's Calhoun Cardiology Centre.

Type 2 Diabetes And Heart Disease a Dangerous Combination
The study included more than 5,300 people around the world with type 2 diabetes. Those admitted to the hospital for congestive heart failure had a 24 percent to 28 percent chance of dying within 18 months.

That's five times higher than the risk among those not hospitalised for a major heart problem, the researchers said.


The risk of heart disease is two to three times higher among people with type 2 diabetes than in the general population, the study authors pointed out.

In all future studies of type 2 diabetes and heart disease, heart failure outcomes should receive the same amount of scrutiny as stroke, heart attack and unstable angina, White said in a university news release.

The reason heart disease and type 2 diabetes are linked is partly because obesity and problems such as high blood pressure and high cholesterol levels contribute to both conditions.

But there are also concerns that some medications to control blood sugar in people with diabetes may also damage the heart, according to the researchers.

The study, to be presented Saturday at the American Diabetes Association's annual meeting in New Orleans, was also published online in the journal Diabetes Care.

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Experimental Migraine Drug Brings Fast Relief

New drugs block a chemical in the nervous system that causes inflammation and blood vessel dilation, spiking in the brain during migraine attacks

Experimental Migraine Drug Brings Fast Relief - An experimental drug may bring fast relief to people with debilitating chronic migraines, a new study finds.
Experimental Migraine Drug Brings Fast Relief

Quick action

Preliminary trials had already found that the drug dubbed TEV-48125 can help prevent migraine attacks in people who've suffered long-term with headaches.

Now, the new findings suggest that it starts working within three to seven days of the first injection, researchers reported.

"To my knowledge, that's the fastest separation ever demonstrated in chronic migraine," said lead researcher Dr Marcelo Bigal, of Teva Pharmaceuticals, the company developing TEV-48125.

The term "separation" refers to the point at which patients on TEV-48125 started to improve, compared to patients given a placebo (an inactive treatment).

TEV-48125 is one of a new class of drugs being developed to prevent migraines. The medications are all antibodies that block a chemical in the nervous system called CGRP. Research has found that CGRP causes inflammation and blood vessel dilation, and it spikes in the brain during migraine attacks.

Exciting findings

Dr Mark Green is professor of neurology and anaesthesiology at the Mount Sinai Icahn School of Medicine, in New York City. "It appears that this antibody works quite quickly," said Green, who is also director of the Centre for Headache and Pain Medicine at Mount Sinai.

Green, who was not involved in the study, called the findings "exciting". That's in part because if CGRP-blockers make it to the market, they would be the first drugs specifically designed to prevent migraines.

About 12 percent of Americans suffer from migraines, according to the U.S. National Institutes of Health. The headaches typically cause an intense throbbing pain on one side of the head, and sensitivity to light and sound. Some people have nausea, too.

Migraines are considered chronic when they strike at least 15 days out of the month, the study authors said.

Doctors prescribe various medications that can help prevent frequent migraines including certain blood pressure drugs, antidepressants and Botox injections. But, Green pointed out, all of those drugs were originally designed to treat other conditions. Over the years, doctors have found that they can also reduce migraines in some people.

Reanalysis of an early trial

And of those drugs, Botox is the only one that is actually approved for preventing migraines, Green said.

When Botox works, it typically takes two or three rounds of injections for patients to start seeing the benefit, according to Green. And those treatments are done at three-month intervals. So some patients give up on it, he said.

The oral medications used for migraine prevention kick in faster – typically four to six weeks. But they are also daily pills with potential side effects, such as weight gain, dizziness and fatigue (depending on the medication), Green said.

The new study findings come from a reanalysis of an early trial of TEV-48125. In that study, more than 250 patients with chronic migraine were randomly assigned to take monthly injections of the drug – at a higher or lower dose – or a placebo, for three months.

The original study found that patients on TEV-48125 saw a drop in the number of hours they had headache pain each month.


Few side effects

On average, the whole study group had 162 "headache hours" a month when it started the study. Three months later, that had dropped by 60 to 67 hours, on average, among patients on the new drug.

The new study found that the effects started as early as three days after the higher-dose injection, and seven days after the lower dose.

So far, Green said, there have been "no significant safety signals" with the drug. In the original study, the most common side effects were pain at the injection site and skin irritation.


But it's still early, Green stressed

Bigal said ongoing studies will keep looking at the drug's safety. "No treatment-related serious adverse events have been seen so far," he said.

If TEV-48125 or its competitors are approved, it's unlikely that patients will be put off by having to take a monthly injection, according to Green.

"These are people in chronic pain," he pointed out

But cost could be an obstacle: In general, antibody drugs like TEV-48125 are very expensive. So patients might find it difficult to get insurance coverage, Green said.

The study was published online in Neurology.

Read more : How to handle ramadhan headaches
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10 Facts You Should Know About Zika

Here are 10 points about Zika virus disease

10 Facts You Should Know About Zika - We’ve all seen the word “Zika” splashed across the headlines and most of us are aware that it has something to do with Brazil and babies with small heads. Many people, however, don't know what all the fuss is about, how it affects us and if we should be worried at all.
10 Facts You Should Know About Zika

Here are 10 facts about Zika:

1. The word “Zika” refers to a virus. The virus belongs to the family Flaviviridae and the name derives from the Zika forest in Uganda where it was isolated in 1947 in monkeys. It was identified in humans in 1952 in Uganda and Tanzania.   

2. The Zika virus is spread to humans mainly through the bite of an infected Aedes aegypti or Aedes albopticus mosquito. These are the mosquitoes that also spread the dengue and chikungunya viruses. They usually bite during the daytime. Zika virus infection can be confirmed by laboratory tests on body fluids like blood, urine, saliva or semen.

3. Before 2015, Zika outbreaks occurred in parts of Africa, Southeast Asia and the Pacific islands. It has since spread to Brazil and, according to the WHO, from 1 January 2007 to 6 April 2016, Zika virus transmission was documented in a total of 62 countries and territories. The virus is likely to continue spreading and it is difficult to predict where it will spread to and how long it will take.  

4. The symptoms of Zika virus disease are similar to dengue, and include:
Fever
Skin rashes
Conjunctivitis
Muscle and joint pain
Malaise
Headache
Symptoms tend to be mild and last for two days to a week. The incubation period is estimated to be a few days. There is currently no drug treatment or vaccine for Zika virus disease.

5. Known complications of of Zika virus disease, according to the WHO, are microcephaly and Guillain-Barré syndrome. There may be a link between the Zika virus and a number of neurological disorders. Microcephaly is a birth defect where babies’ heads are smaller than those of their peers. It is also associated with incomplete brain development. Guillain-Barre syndrome is a condition where the immune system attacks nerves, leading to muscle weakness and sometimes paralysis.

6. The Zika virus can also be transmitted:
From mother to child. A pregnant mother can pass the Zika virus to her foetus while she is pregnant.  
Through sexual contact. The virus can be spread by a man to his sex partners.
Through blood transfusion. There have been a large number of blood transfusion cases in Brazil and the virus has been found in blood donors in other countries.
Through laboratory exposure. There have been four reports of laboratory acquired Zika virus infections.

7. South Africa is not likely to be at risk of Zika, according to The National Institute of Communicable Diseases (NICD) – even though Zika virus disease is spreading explosively in the Americas. (The Zika virus tends to favour tropical regions.) Professor Lucille Blumberg, a deputy director at the NICD, however, warns that pregnant women should be careful about going abroad, especially to Brazil. 

8. Because Zika can be transferred though sexual intercourse, couples and individuals returning from Zika-affected areas should practise safe sex for at least eight weeks.

9. Zika is not the end of the world. Although it has been declared “a global public health emergency” by the WHO, as stated above, most people who contract Zika virus disease have very mild symptoms. The link between the Zika virus and microcephaly has also not been conclusively proven, only "strongly suspected".

10. There is definitely no need for the Olympics to be cancelled, postponed or moved. In response to the news that golfer Rory McIlroy withdrew from the Olympics over Zika fears, an expert said that only pregnant women and people planning a family need fear Zika.
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How to Handle Ramadan Headaches

Ramadan is a sacred, spiritual time for Muslims around the world but fasting can cause headaches. This is how you can prevent and manage headaches during this holy month


How to Handle Ramadan Headaches - Ramadan is a sacred time for Muslims worldwide. During this one-month period Muslims fast from sunrise to sunset.

Studies have shown that the religious practice of fasting (abstaining from eating, drinking or smoking) can often lead to mild or moderate headaches. Fortunately for those that get headaches during Ramadan, there are some ways to help prevent headaches during Ramadan.
How to Handle Ramadan Headaches
Research shows that Ramadan headache onset often occurs in the afternoon or evening just before the fast is broken. Headache frequency typically increases over the duration of fasting. Those prone to headaches at other times of the year are most likely to get a headache when fasting, but some patients who experience headaches during this time often have no previous history of headaches or migraines.

Dr. Elliot Shevel, South Africa’s migraine surgery pioneer and the medical director of The Headache Clinic, says headaches during fasting can occur as a result of a few factors such as low blood sugar, increased stress, and caffeine withdrawal.

The good news is that you can manage these headaches without breaking your fast.


1. Caffeine withdrawal

Caffeine withdrawal is a common cause of headache while fasting. “Patients can often prevent headaches by reducing caffeine consumption in the weeks leading up to their fast,” says Shevel. A cup of strong coffee just before the start of the fast each day may also prevent caffeine withdrawal headache.

2. Hypoglycaemia

Hypoglycaemia (low blood sugar) can also trigger headaches in many people. If a meal with high sugar content is taken before the fast begins, it can cause a rapid rise in blood sugar levels, followed by a fast drop that may trigger a headache, explains Shevel.

“Eating a meal with low sugar content before the fast may prevent the onset of a headache during the day.” Contact The Headache Clinic for a list of foods which have a low glycaemic index.

3. Dehydration

Dehydration is another common trigger and adequate intake of fluid before the onset of the fast can often prevent headaches.

“The human brain consists mostly of water, and it is very sensitive to the amount of water available to it. When the brain detects that the water supply is too low, it begins to produce histamines,” explains Shevel.

This is essentially a process of water rationing and conservation, in order to safeguard the brain in case the water shortage continues for a long period of time. The histamines directly cause pain and fatigue, in other words a headache and the low energy that usually accompanies it. Make sure to drink large amounts of water before starting your fast and when you end it.

Avoid triggers

“Patients should also, as far as possible, try to avoid exposure to other triggers such as stress, fatigue and lack of sleep during their fast, when there is a greater tendency to experience headache,” says Shevel. “Rest and sleep often help prevent being subjected to headaches and the pain often melts away when the fast is broken.”

When to call your doctor

If headaches are interfering with your fast, contact The Headache Clinic as we have a number of techniques to relieve you of your pain. This will allow you to continue your fast without having your focus be overtaken by persistent headaches. If headaches persist after the fast or are severe in nature, patients are advised to seek help from a medical professional. Shevel explains that headaches can be most successfully treated using a multidisciplinary approach, since no one medical specialization covers all the psychological and physical dimensions of severe headaches.
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Cat Bites May Lead To Serious Infections

When cats bite, their sharp teeth can inject hard-to-treat bacteria deeply into the skin and joints, increasing the risk of serious infection

Cat Bites May Lead To Serious Infections - Cat bites may look less serious than dog bites, but beware: They can cause dangerous infections, particularly when they involve the hand, new research indicates.

Although cats have no more germs in their mouths than dogs or people, researchers at the Mayo Clinic found that when cats bite, their sharp teeth can inject hard-to-treat bacteria deeply into the skin and joints, increasing the risk for serious infection.
Cat Bites May Lead To Serious Infections

Cats' teeth are sharp

"Dogs' teeth are blunter, so they don't tend to penetrate as deeply and they tend to leave a larger wound after they bite," study senior author Dr. Brian Carlsen, a Mayo Clinic plastic surgeon and orthopaedic hand surgeon, said in a clinic news release. "Cats' teeth are sharp and can penetrate very deeply. They can seed bacteria in the joint and tendon sheaths."

"It can be just a pinpoint bite mark that can cause a real problem," he said, "because the bacteria get into the tendon sheath or into the joint where they can grow with relative protection from the blood and immune system."

The researchers studied nearly 200 cat bite cases that occurred between 2009 and 2011. The patients involved in the study were all bitten on the hand. The average of the participants was 49 years old, and 69% were women.

About half the patients visited an emergency room, while the rest went to their primary-care physician. The average time people waited between getting bitten and seeking treatment was 27 hours.

Reconstructive surgery

The researchers said 57 of the patients who were bitten needed to be hospitalised, but only 36 had been admitted immediately after seeking medical treatment.

Of those admitted to the hospital, 38 patients needed surgery to clean the wound or remove infected tissue. The study, published in the Journal of Hand Surgery, also revealed that eight patients needed more than one surgical procedure, and some needed reconstructive surgery.

Meanwhile, 80% of the patients were initially prescribed oral antibiotics, the researchers said. For 14% of these patients, outpatient treatment with antibiotics didn't work and they needed to be hospitalised.

In most cases, bites that were positioned directly over the wrist or another joint were more likely to result in hospitalisation than bites to soft tissue, the researchers said.

Cat bites need to be taken seriously

Cat bites need to be taken seriously and carefully evaluated by doctors, the study authors said. This is particularly true when patients develop inflamed skin and swelling. In these cases, the researchers said, the wound should be treated aggressively.

"Cat bites look very benign, but – as we know and as the study shows – they are not," Carlsen said. "They can be very serious."
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There Are Many Things You Could Do To Avoid a Bad Hair Day

There Are Many Things You Could Do To Avoid a Bad Hair Day - Sandra’s hair took a knock during her pregnancy, Mike has thick hair which is the envy of many women (and men), while David is very worried about his receding hairline. He rather fancies himself as a ladies’ man, which is quite difficult to pull off if you're involuntarily bald at his age. And Margot’s hair has taken a fair battering over the years with perms and colourants.
There Are Many Things You Could Do To Avoid a Bad Hair Day
Whether you have long hair, short hair or very little hair, it needs care. Regular shampooing of hair and cleansing of the scalp is of course, essential. We have hair to provide some protection for the scalp and head against the sun and a few hard knocks. It also helps to insulate us against heat and cold.

Read More : Four Tips For Healthy Winter Hair


Read More : SA Women Depressed Over Early Hair Loss

A few things to remember:


Basic hair care starts with clean hair.
All hair is not created equal – some people have dry hair, others have oily hair and then there is quite a variety of combinations in between.
Too much washing can, however, damage the hair as it washes away the sebum, an oily substance that protects our hair and makes it shiny.
Good shampoos only remove excess oil.
Low ph shampoos should be used by women with dry, permed, damaged or straightened hair.
Anti-dandruff shampoos work, but they can be fairly harsh, so they should be used in conjunction with hair conditioner.
Don’t brush your hair too much. You could be adding to split ends.
Remember that a balanced diet containing proteins and vitamins is more important than expensive conditioners.

Read More : How Your Lifestyle Triggers Hair Loss
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Omega-3 may have disadvantages

Omega-3 fatty acids, often taken to boost health, may increase childhood allergies and prostate cancer, say researchers

Omega-3 may have disadvantages - Omega-3 fatty acids, often taken to boost health, appear to increase the risk of childhood allergies and prostate cancer, according to two recent studies.

Newborns with high levels of unsaturated fats in their blood were more prone to develop an allergy than those with lower blood concentrations, Swedish experts have discovered.

"It is already known that unsaturated fatty acids inhibit activation of the immune system. This can be useful when you are old," Agnes Wold, a physician at the clinical microbiology department of Gothenburg's Sahlgrenska University Hospital, said in a statement.

Omega-3 may have disadvantages


"But a baby's immune system needs to get a kick-start, otherwise it does not develop properly," said Wold.

Previous research has indicated that children who at an early age were given fish, which is famously high in omega-3 fatty acids, were less likely to get an allergy.

Prostate cancer concerns
Separately, a study published in Britain's Journal of the National Cancer Institute found that three omega-3 fatty acids were associated with an increase of between 43% and 71% in the risk of developing prostate cancer.

The biggest increase in risk was for so-called high-grade prostate cancer, whose tumours are more likely to be fatal.

Led by scientists from the US Fred Hutchinson Cancer Research Center, the study amplifies previous findings in 2011 that suggested these fatty acids play an unexplained role in initiating prostate cancer.

"Recommendations to increase ... [omega-3] intake, in particular through supplementation, should consider its potential risks," said the research paper.

In May, an Italian-led study also showed that fish oil supplements rich in omega-3 fatty acids were not beneficial for patients at high risk of cardiovascular troubles and already under medication.

Previous clinical trials had suggested the supplements could reduce cardiovascular risks for patients suffering from cardiovascular disease or who had already suffered cardiac arrest.

However, people were cautioned against avoiding fish on the basis of these findings.

"Fish is so much more than just omega-3 fatty acids. One cannot conclude from our study that pregnant women and young children should not eat fish," said co-author, Prof Ann-Sofie Sandberg.
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Diabetes Raises Risk Of Heart Disease In Women

Type 2 diabetes in itself, regardless of other risk factors, increases the risk of heart disease in women, a new study finds

Diabetes Raises Risk Of Heart Disease In Women - Type 2 diabetes in itself, regardless of other risk factors, increases the risk of heart disease in women, a new study finds.

The study included nearly 1 300 Argentine women, aged 19 to 84, with and without type 2 diabetes. They underwent ultrasound imaging to measure plaque in their carotid arteries, large arteries in the neck that supply blood to the brain.
Diabetes Raises Risk Of Heart Disease In Women
Plaque build-up in the carotid arteries was more common among the nearly 300 women with type 2 diabetes than in women without the disease. This was true regardless of age, family history, smoking history, having high blood pressure or menopausal status.


The findings were scheduled for presentation Thursday at an American Heart Association meeting in New Orleans. The data and conclusions should be viewed as preliminary until published in a peer-reviewed journal.

"To reduce the risk of heart attacks, we recommend screening women with type 2 diabetes at younger ages, even if they don't have other known risk [factors] for heart disease," study author Dr Nestor Garcia said in an AHA news release.

Although the study suggested type 2 diabetes is independently associated with heart disease in women, it did not prove a cause-and-effect relationship.

Heart disease is the leading cause of death among Americans and is caused by the gradual build-up of plaque in the arteries, according to the news release. A growing number of Americans have type 2 diabetes, one of the major risk factors for heart disease.

More information

The U.S. Centers for Disease Control and Prevention has more about heart disease

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Finding a Personal Trainer

Right, so it's you're all pumped to get going on a more effective exercise regime, but where do you find a trainer who can make the critical difference? FitnessDoc has some ideas

Finding a Personal Trainer - Right, so it's you're all pumped to get going on a more effective exercise regime - but where do you start to find a trainer who can make the critical difference? And what's the difference between a personal trainer and a biokineticist?
Finding a Personal Trainer
According to Health24's FitnessDoc, Ross Tucker, word of mouth is the way to go when looking for a personal trainer that will suit your needs.

"At the moment there is no clearly defined controlling body for accreditation and training of personal trainers, although there are perhaps four or five large, established training providers. ETA is perhaps the most well known, as well as Reebok Alliance, Bodyline and the Health Professionals Fitness Alliance (HPFA)," he said.

He added that while one has a better chance of striking it lucky and finding a good personal trainer if they've come through one of the abovementioned bodies, there are also good personal trainers who have qualified through smaller institutions.

Biokineticists vs. personal trainers – what's the difference?
"The relative lack of control among personal trainers in the industry is perhaps the biggest reason why I personally would advocate that someone seeks out the advice of a biokineticist for specific training queries.

"This will no doubt label me an academic 'snob'," says Tucker, "and I certainly don't wish to generalise, but when a person sees a biokineticist, they are assured that the person has come through at least four years of university training, plus a full year of practical experience training. That level of qualification and training ensures a much higher quality of service in most cases."

However, he reiterated that the best way to find a good trainer is through word of mouth: as "a trainer's reputation is very easy to identify and establish", he pointed out. So ask around, and bear in mind that a technically highly skilled person might not be a compatible person: it's not called a personal trainer for nothing. If you don't click, and if if your trainer doesn't "get" your personality, it's not going to be a great experience.

"Once a trainer is identified, they must be held to the highest performance standard – which is actually the responsibility of the client. I feel that too often, clients/members of public accept sub-par service, when they should demand the very best.

"The problem is that personal trainers often stretch themselves too thin, across too many clients at one time and so provide a lacklustre service to all but a few clients. Every member of the public must demand the best, with no allowances being made," Tucker said.

Check out the following sites:
Exercise Training Academy (ETA) at www.exerciseacademy.com
Reebok Instructors Alliance at www.reebok.co.za
Bodyline Fitness Academy at www.bodyline.co.za
Health and Fitness Professionals Association at www.hfpa.co.za

Read More : Here's An Excellent Weekly Plan To Walk Off 5kg
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How To Spot a Bad Trainer

A personal trainer who has not been properly trained can do you a lot more harm than good. Here are the things you should look out for

How To Spot a Bad Trainer - If you can afford it, having a personal trainer is a great route to take to achieve your fitness goals safely and effectively. However, if your personal trainer isn't up to scratch, not only will they add nothing to your fitness regime, but they can actually cause you to suffer injury.
How To Spot a Bad Trainer
Always do a little research around your choice, and check their references. The experts always also have some suggestions about how to tell the good from the bad:

When good trainers go bad
According to Robyn Morgan of Flex Ladies Health and Fitness Centre in Cape Town, one of the most common mistakes personal trainers who are not properly trained or are inexperienced make, is to give each of their clients the same workout programme. It's essential, she said, to cusomise programmes according to clients' abilities and goals.

Morgan suggests the best way to find a qualified trainer is to look for someone with a background in physical education or coaching.

"The trainer should look at you as a whole, and not just in terms of centimetres and weight. It's important that you like the trainer and feel comfortable with him or her, as well. I think word of mouth is the best referral."

JC Moolman, medal winning SA athlete and personal trainer at The Zen Studio in Table View agreed with this and said nothing made her cringe more than watching someone at the gym in the hands of a trainer who was clearly not qualified. According to her, what separates the good from the bad is experience and people skills.

"If you're looking for a trainer, watch how they work and how they train their other clients to get an idea of their style and ability", she suggests.

Spotting that bad trainer
So how do you spot these under-trained trainers in a gym environment? According to Morgan, if you already have a trainer and an injury occurs, or if injury is ongoing occurrence with every workout and it is not dealt with but avoided, it could be time to find another trainer.

Should your trainer neglect to make sure that you are doing the exercises correctly, and fail to correct your posture when you're doing exercises – it could be time to move on to a better trainer.

Top of the list for when to lose your trainer? "Any trainer that encourages you to take anabolic steroids is a big no-no," says Morgan.

Moolman's list of mistakes made by bad trainers includes "overbooking themselves, then being tired as a result and not paying proper attention to the client. A good trainer gives a full attention and explains every exercise, where on the body it works, what it does and how the muscles work," she said.

What's the big deal?
Apart from the fact you're shelling out your hard-earned cash on someone who is not earning it, poor training can have some devastating physical repercussions.

"Poor training can result in permanent injury or make an existing orthopaedic condition worse. If your potential and individuality are not accurately analysed, and if you are not taught in a scientific way, you can get hurt," Morgan said.

Moolman said that if you have been working out with a trainer for a while and you're still not seeing any results, if they do not explain how the exercises work and why you're doing them, if they over-train you to the point where you can't walk for days… it could be time to do a little spring-cleaning and rather find yourself a qualified trainer.

Sources: Robyn Morgan, Flex Ladies Health and Fitness Centre; www.flex.co.za
JC Moolman, personal trainer, award-winning athlete; The Zen Studio, www.zenstudio.co.za

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Here's An Excellent Weekly Plan To Walk Off 5kg

Here's an excellent weekly plan to walk off those excess kilos without getting bored.

Here's An Excellent Weekly Plan To Walk Off 5kg If you’re finding it tough to get back into your gym routine – don’t! Our easy-to-follow walking programme will get you slim outside.
Make the most of the spring weather with these easy but powerful workouts.
Here's An Excellent Weekly Plan To Walk Off 5kg
Research shows that routines like these can significantly lower your risk of heart disease, diabetes, and stroke.
Yes, walking has had a bad rep in the past, thanks to its yawn factor and less-than-stellar kilojoule burn, but our program eliminates those problems.
You’ll alternate between three walks (take a different route each time), so you’ll never do a single one more than twice a week.
And because picking up the pace can increase the kJ burn by 50 percent, you’ll vary your speed. See how much weight you can lose the easy way — and you can brag that you did it without setting foot in a gym.
Weekly plan
Day 1 Walk 1, the Energising Blast
Day 2 Walk 2, the 3 kilometre Fat Burner
Day 3 Walk 3, the Power Hour
Day 4 Repeat Walk 1, the Energising Blast
Day 5 Repeat Walk 2, 3 kilometre Fat Burner
Day 6 Repeat Walk 3, the Power Hour
Day 7 Off
If you’re just starting to exercise, rest on Days 4 and 7 and repeat Walks 1 and 2 on Days 5 and 6.
How it works
For each walk, choose a route that matches the specified distance and includes hills.
Use a pedometer if you have one, to track your mileage, or follow our time estimates instead. Adjust your speed to meet the rate of perceived exertion (RPE).
An easy pace is closest to your everyday speed. A moderate pace is the one you’d use if you were late. A brisk pace should feel like you’re just about to break into a jog.
Walk 1
Energising Blast
Distance 1.5 km
Time 22 min (will vary based on your pace)
Kilojoules burnt 750
DISTANCETIMEPACERPE
0.25 - 0.354:30 - 5:30brisk6
0.35 - 0.455:30 - 7:00moderate5
0.45 - 0.557:00 - 8:00brisk6
0.55 - 0.658:00 - 9:30moderate5
0.65 - 0.759:30 - 10:30brisk6
0.75 - 1.0010:30 - 14:30moderate5
1.00 - 1.2514:30 - 17:30brisk6 - 7
1.25 - 1.5017:30 - 22:00easy3
Walk 2
Three-KM Fat Burner
Distance 3 km
Time 45 min (will vary based on your pace)
Kilojoules burnt 1 254
DISTANCETIMEPACERPE
0 - 0.250 - 4:30easy3
0.25 - 0.504:30 - 7:30brisk6
0.50 - 0.757:30 - 11:15moderate5
0.75 - 1.2511:15 - 17:45brisk6
1.25 - 1.7517:45 - 25:15moderate5
1.75 - 2.2525:15 - 31:45brisk6-7
2.25 - 2.5031:45 - 35:30moderate5
2.50 - 2.7535:30 - 38:45brisk6
2.75 - 3.0038:45 - 45:00easy3
Walk 3
Power Hour
Distance 5 km
Time 1hr 15 mins (will vary based on your pace)
kJ burnt 1 672
DISTANCETIMEPACERPE
0 - 0.500 - 7:30easy to moderate3-4
0.05 - 0.757:30 - 10:45brisk6-7
0.75 - 1.2510:45 - 18:15moderate5
1.25 - 1.7518:15 - 24:45brisk6
1.75 - 2.7524.45 - 39:45moderate5
2.75 - 3.2539:45 - 46:15brisk6-7
3.25 - 4.2546:15 - 61:15moderate5
4.25 - 4.5061:15 - 64:30brisk6
4.50 - 5.0064:30 - 75:00moderate to easy3-4
Walking tips
The kilometres will fly by — with no cramps or stiffness — if you focus on these pointers, says exercise physiologist, Michael Brazeal:
  • Look straight ahead; your chin should be parallel to the ground.
  • Keep your elbows bent and close to your sides.
  • Swing your arms forward, then drive your elbows behind you (don’t cross your arms in front of your torso).
  • Pull your shoulders back and keep your chest slightly lifted.
  • Keep your fists loose (imagine you’re lightly holding walking poles).
  • Push off strongly from the balls of your feet. The heel of your front foot should hit the ground first, then roll through to your forefoot.
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Zika Virus Spreads To More Tropical Destinations

The updated alert issued by the Centres for Disease Control and Prevention brings the total to 22 destinations, mostly in Latin America and the Caribbean

Zika Virus Spreads To More Tropical Destinations - Health authorities have added eight tropical destinations to a travel alert – because of an illness linked to a severe birth defect, and spread by mosquitoes.
Zika Virus Spreads To More Tropical Destinations

Abnormal brain development


The new locations are Barbados, Bolivia, Ecuador, Guadeloupe, Saint Martin and Guyana, Cape Verde, off the coast of western Africa, and Samoa in the South Pacific.

Last week's alert included Brazil, Colombia, El Salvador, French Guiana, Guatemala, Haiti, Honduras, Martinique, Mexico, Panama, Paraguay, Puerto Rico, Suriname and Venezuela.

The CDC says pregnant women should consider postponing trips to these destinations because the virus has been linked with microcephaly. Affected newborns have unusually small heads and abnormal brain development.

All travellers to these areas are advised to take precautions, including using insect repellent and wearing long sleeves and long pants, to avoid mosquito bites.

Zika illness can cause fever, rash and joint pain but most people infected by mosquito bites don't show symptoms. There's no specific treatment; infected people aren't contagious.

The CDC says people who do develop symptoms should tell their doctors where and when they travelled.
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Animal And Human Bites

Dogs are the most likely pets to cause animal bites. However, cat and human bites are far more dangerous

Animal And Human Bites - Dogs are the most likely domestic pets to cause animal bites. Most cases involve children. Cat and human bites, however, carry a higher risk of infection. Apart from causing injury and septic wounds, there is a chance that animal bites may transmit tetanus and, in rare cases, rabies.
Animal And Human Bites

Home treatment:


If the wound barely breaks the skin, treat it as a minor wound. Scrub the bite thoroughly with soap and running water. Apply antibiotic cream and a loose sterile bandage.
If the bite creates a deep puncture of the skin or the skin is badly torn, allow for some bleeding to cleanse the wound and see your doctor.
If the animal has an identifiable owner, enquire whether it is currently vaccinated against rabies. Even if that is the case, it should be observed and quarantined by a veterinarian for the next 10 days to see if it develops symptoms of rabies.
If the animal is stray, wild or there is no documented proof of vaccination, contact the local health department. The animal should be assumed as being positive for rabies and you should start receiving treatment for rabies within 48 hours (see below). If the animal is caught, it should be euthanised to test for rabies. Only if the test is negative, can treatment be stopped.
See a doctor if :

The wound is deep, especially if it is a puncture wound. Cat and human bites (even cuts on knuckles caused by a fight) should always be seen by a doctor.
You have been bitten on the face, hand, foot or neck, or over a joint.
You suspect that the animal may be rabid or the bite is from a wild or stray animal, or if definite proof cannot be found of current vaccination of the animal.
You haven't had a tetanus injection within the past five years.
There are signs of infection.
Prevention of dog bites

Most dog bites can be prevented. Teach children not to disturb dogs while they eat, sleep or care for puppies. Children should never be left alone with a dog. Neuter your dog.
If a dog approaches, stay calm. Teach your children to stand still – "like a tree". Never pet a dog without letting it sniff you.
If a dog threatens to attack, stay calm, talk in a firm voice and avoid eye contact. Don't scream. Back away slowly and don't turn and run – a dog will always outrun you.
If a dog attacks, curl up into a ball to protect your face, neck and head.

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Rehabilitation After a Stroke

A stroke is the third most common cause of death in South Africa and occurs when a clot stops the blood flow to the brain or because an artery breaks or bursts

Rehabilitation After a Stroke - Sometimes there is only temporary damage to brain cells so they can continue functioning with therapy. Yet, in most cases, rehabilitation is started as soon as possible so that the patient can return to a normal life.
Rehabilitation After a Stroke

Treatment options 

Most victims require immediate hospital treatment where they are given fluids to prevent dehydration and physiotherapy to prevent pneumonia. They require constant physical attention, including being repositioned in bed, and given skin care to prevent bedsores. In severe cases, emergency neurosurgery may be needed to remove blood clots or repair a ruptured aneurysm. 

Ischemic stroke

Emergency treatment for an ischemic stroke depends on the location and cause of the clot. Intravenous (into the veins) fluids and medications such as clot dissolving drugs and anti-platelet drugs are administered.

The majority of strokes are caused by blood clots which shift to a blood vessel in the brain and block blood flow to that area. This type of stroke is known as an ischemic stroke and thrombolytics are most commonly the drugs used within three hours of the first stroke symptoms.


What is thrombolytic therapy?

Thrombolytic therapy refers to the use of drugs to break up blood clots, which are the chief cause of heart attacks and stroke. The most commonly used drug for thrombolytic therapy is tissue plasminogen activator (tPA) and research suggests your survival and recovering chances are greatly improved if you are given a thrombolytic drug within 12 hours.

They work by dissolving a major clot which restarts blood flow to the heart and helps prevent damage to the heart muscle. 

How thrombolytic treatment works
The most common way this treatment is performed is to inject clot-dissolving medications into a blood vessel where they then flow through the bloodstream to the clot, and dissolve it.
Another way is via a catheter which is inserted through the blood vessel to the area of the clot where it delivers the medications.
Not everyone is a candidate for thrombolytics, and deciding factors include:

•    Age
•    Gender
•    Medical history 

You may be refused one of you have any of the following because of the increased risk of bleeding associated with these conditions.

•    Active bleeding or severe blood loss
•    Severe high blood pressure 
•    A recent head injury
•    A stroke from bleeding on the brain (a haemorrhagic stroke)
•    Bleeding ulcers
•    Liver disease
•    Pregnancy
•    Recent surgery

Haemorrhagic stroke

Surgery may be used to treat a haemorrhagic stroke or prevent recurrence. The most common procedures include aneurysm (weakened or ruptured blood vessel) clipping and the removal of arteriovenous malformation (AVM) - masses of abnormal blood vessels in the brain. Both surgeries carry high risks.

Recovery 

Whether it’s for ischemic or a haemorrhagic stroke, rehabilitation is vital. Some have difficulties such as speech and movement affecting recovery and rehabilitation.

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Stem Cells Offer New Hope To Stroke Survivors

Neurosurgeons are getting promising results by injecting modified stem cells 

Stem Cells Offer New Hope To Stroke Survivors - Preliminary research suggests that injecting adult stems cells directly into the brain may give stroke patients a new shot at recovery long after their stroke occurred.
Stem Cells Offer New Hope To Stroke Survivors

'Blown away'


"We don't want to oversell this," stressed study lead author Dr Gary Steinberg, chair of neurosurgery at Stanford University School of Medicine in Palo, Alto, California.

"This isn't the first stem cell trial for stroke, and we're in the early phase, with only 18 patients. But after injecting stem cells directly into the brain of chronic stroke patients, we were blown away," he said.

"These were patients who had significant motor deficits for six months or more," said Steinberg. "People who had a hard time moving their arm or leg, or walking. People for whom we have no real treatment. But after the injections we saw improvement in all 18 patients, as a group, within a month. Within days some were lifting their arms over their head. Lifting their legs off their bed. Walking, when they hadn't in months or years. The results were very exciting."

About 800,000 Americans experience a stroke every year. There are roughly 7 million chronic stroke survivors in the United States. Many of these survivors end up facing a new reality, in which lost motor function is unlikely to return, the researchers said.

Unexpected results


"We're used to 90 percent or more of stroke recovery taking place in the first six months," Steinberg said. "So the thinking has been that we really can't restore function in chronic stroke patients because their circuits are dead."

But the new research set out to upend this thinking.

First, the research team selected people who had severe, but not extreme, motor impairment from a stroke. Most had experienced their stroke at least one year prior to the study launch. Their average age was 61.

One such patient was Long Beach, California., resident Sonia Olea Coontz.

"I was 31 when I had my stroke on May 14, 2011," she said. Between then and her 2013 enrolment in the trial, Coontz struggled with a debilitating loss of mobility.

"I could only move my right arm very little," she recalled. "And I was in a lot of pain. Same with my leg. Walking was very difficult. Every time I went to the hospital I was in a wheelchair because it was just a lot easier. And speaking was hard. I always needed someone to help me communicate."

Read: Stem cells from lipo leftovers

The experimental stem cell procedure began with doctors drilling a small hole through the skull. Patients had minimal anaesthesia. In turn, neurosurgeons injected modified stem cells directly into multiple areas of the brain near the site of each patient's stroke.

Gains maintained


The result: with no apparent blood abnormalities or significant side effects, all of the patients experienced significant motor control recovery within the first month. Younger patients tended to fare better, the investigators found.

Mobility continued to improve throughout the first three months. Gains were maintained at both the six month and one-year follow-up.

"After the surgery I was immediately better," said Coontz. "It was amazing. After the surgery the pain in my shoulder was gone. My arm, I could move it all the way up to the ceiling and back. And my leg was stronger. I didn't use a wheelchair after that. Ever."

Read: Regenerative medicine: replacing brain cells lost from stroke

And, she added in a clear voice, "I was also much better with speaking. I still needed a little help. But my words were stronger. And it continued to get better. Even now it's still getting better."

How do the stem cells seem to help?


"We're still not exactly sure what's happening," admitted Steinberg. Because the stem cells tend to die off one to two months following injection, he suggested that "it's probably not that the stem cells are becoming neurons and reconstituting circuits. That's not what appears to be going on."

Dr Ralph Sacco is chairman of neurology at the University of Miami's Miller School of Medicine. "A lot of people assume that the point of stem cells is that they will become new brain cells," he said.

Jumpstarting circuits


"But in fact, we know that much of stroke recovery seems to take place in the parallel or surrounding or connecting regions next to the damaged stroke area," he added. Sacco is also the president-elect of the American Academy of Neurology.

"The latest thinking is that the big virtue of stem cells – in addition to their anti-inflammatory and immunological effect – may be their ability to secrete chemicals that activate those surrounding brain cells so that they can start to pick up function for the parts of the brain that no longer work right," Sacco said.

"In other words," Steinberg said, "we think these cells turn the adult brain into a neonatal or infant brain. And infants recover very well after a stroke, because their brains have greater plasticity, and the ability to form new connections between cells already in the brain."

Steinberg said that "somehow putting these stem cells directly into the brain jumpstarts circuits we had thought were irreversibly damaged or dead, with remarkable results."

But as the research team embarks on a larger study involving 156 chronic stroke patients, Sacco urged caution.

"The results do sound amazing," he said. "But keeping in mind that everyone has long been looking for a miracle cure for stroke. It's really premature to draw conclusions. This is one very small study that was really set up to establish safety. More work will be needed."

But for patients like Coontz, the jury is already in.


"The other treatments before surgery didn't work," she said. "Not really. I felt like my whole body was dead. Like it wasn't working at all. Rehab didn't help. But after the surgery, it felt like my body was all of a sudden awake."

The study was published online in the journal Stroke.
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